A
Omega-3 Fatty Acids and Inflammatory Processes
Calder PC • Biochem Soc Trans • 2017
EPA and DHA reduce inflammation through multiple mechanisms including resolvin synthesis.
omega 3Inflammationimmunology
Curated scientific studies with plain-English summaries and multi-paradigm interpretation
Showing 20 studies
Calder PC • Biochem Soc Trans • 2017
EPA and DHA reduce inflammation through multiple mechanisms including resolvin synthesis.
Varbo et al. • Circulation • 2016
Remnant cholesterol causes both inflammation and ischemic heart disease
Irwin MR, et al • Biological Psychiatry • 2016
Sleep disturbance associated with elevated CRP (effect size 0.12) and IL-6 (effect size 0.20); long sleep duration associated with higher CRP (effect size 0.17)
Koenig G, Seneff S • Dis Markers • 2015
Framingham: highest GGT quartile HR 1.67 for CVD, HR 2.54 for MetS; Austrian study: GGT >56 U/L men/>36 U/L women = 100% increased mortality risk
Jimenez K, et al • Gastroenterology & Hepatology • 2015
Oral iron absorption maxes at 20-25% of 100mg doses; hemoglobin should increase 2 g/dL within 4-8 weeks with adequate therapy
Minihane AM, et al • British Journal of Nutrition • 2015
An unresolved inflammatory response is likely involved from early stages of disease development; current fasting inflammatory markers represent an insensitive and highly variable index of tissue inflammation
Grosso et al. • Oxidative Medicine and Cellular Longevity • 2014
MDD: effect size 0.56 SD (95% CI 0.20-0.92); EPA-predominant superior to DHA; bipolar disorder effect 0.73-0.74 SD; significant as adjuvant therapy
Zhang Y, Neogi T, Chen C, et al. • Arthritis Rheum • 2012
Cherry intake over 2 days: 35% lower gout attack risk (OR 0.65, 95% CI 0.50-0.85); cherry + allopurinol: 75% lower risk (OR 0.25)
Juraschek SP, Miller ER, Gelber AC • Arthritis Care Res • 2011
Vitamin C supplementation reduced uric acid by 0.35 mg/dL (95% CI -0.66 to -0.03, P=0.032); higher baseline UA (≥4.85 mg/dL) showed 0.78 mg/dL reduction
Emerging Risk Factors Collaboration • Lancet • 2010
Per 3-fold higher CRP: CHD HR 1.37 (1.27-1.48), ischaemic stroke HR 1.27 (1.15-1.40), vascular mortality HR 1.55 (1.37-1.76) after adjustment
Calder PC • Nutrients • 2010
Effective anti-inflammatory effects require >2g EPA+DHA daily; EPA-derived eicosanoids 10-100 fold less potent as inflammatory mediators; new steady-state reached within ~4 weeks
Sanyal AJ, Chalasani N, Kowdley KV, et al. • N Engl J Med • 2010
Vitamin E improved NASH in 43% vs 19% placebo (P=0.001, NNT 4.2); NASH resolution 36% vitamin E vs 21% placebo; neither treatment improved fibrosis
Forsythe CE, Phinney SD, Fernandez ML, et al. • Lipids • 2008
Low-carbohydrate diets may reduce inflammatory markers more effectively than low-fat diets
Choi HK, Curhan G • BMJ • 2008
≥2 sugar-sweetened soft drinks/day associated with RR 1.85 (95% CI 1.08-3.16) for gout; highest fructose quintile RR 2.02 (95% CI 1.49-2.75)
Ridker PM, Danielson E, Fonseca FA, et al. • N Engl J Med • 2008
Statin therapy reduces cardiovascular events by 44% in people with elevated CRP and normal LDL
Feig DI, Kang DH, Johnson RJ • N Engl J Med • 2008
Hyperuricemia (>6 mg/dL women, >7 mg/dL men) associated with hypertension, metabolic syndrome (59% with UA >10 vs 5.9% with UA <6), renal dysfunction; allopurinol reduced BP ~6.9 mmHg in adolescents
Ridker PM • J Am Coll Cardiol • 2007
hsCRP independently predicts myocardial infarction, stroke, diabetes, and all-cause mortality
Selvin E, Paynter NP, Erlinger TP • Arch Intern Med • 2007
Weight loss reduces CRP levels proportionally to the degree of weight lost
Esposito K, Marfella R, Ciotola M, et al. • JAMA • 2004
Mediterranean diet significantly reduces hsCRP and other inflammatory markers