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Research Library

Curated scientific studies with plain-English summaries and multi-paradigm interpretation

Showing 2 studies

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Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications

Miller JW • Advances in Nutrition • 2018

PPIs/H2RAs: HR 1.83 (95% CI 1.36-2.46) for B12 deficiency with ≥10 months use; Metformin: mean B12 reduction of -54 pmol/L (95% CI -81 to -26)

vitamin b12medication interactionsDiabetes

Randomized Controlled Trial

Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial

de Jager et al. • BMJ • 2010

Metformin reduced B12 by 19% (P<0.001); B12 deficiency (<150 pmol/L) NNH 13.8 per 4.3 years; deficiency prevalence 9.9% metformin vs 2.7% placebo

vitamin b12Diabetesmedication interactions