Curated scientific studies with plain-English summaries and multi-paradigm interpretation
Showing 9 studies
Kennedy OJ, Roderick P, Buchanan R, et al. • BMJ Open • 2017
Two additional daily cups of coffee: 35% HCC risk reduction (RR 0.65, 95% CI 0.59-0.72); caffeinated coffee: 27% reduction; decaffeinated: 14% reduction
Koenig G, Seneff S • Dis Markers • 2015
Framingham: highest GGT quartile HR 1.67 for CVD, HR 2.54 for MetS; Austrian study: GGT >56 U/L men/>36 U/L women = 100% increased mortality risk
Loomba R, Yang HI, Su J, et al. • Gastroenterology • 2013
HBV infection significantly increases liver cancer risk
Ruhl CE, Everhart JE • Hepatology • 2012
Optimal ALT cutoffs: men 29 IU/L (88% sens, 83% spec), women 22 IU/L (89% sens, 82% spec); 36.4% of men and 28.3% of women would show elevated ALT using these cutoffs
Sanyal AJ, Chalasani N, Kowdley KV, et al. • N Engl J Med • 2010
Vitamin E improved NASH in 43% vs 19% placebo (P=0.001, NNT 4.2); NASH resolution 36% vitamin E vs 21% placebo; neither treatment improved fibrosis
Fraser A, Longnecker MP, Lawlor DA • Gastroenterology • 2007
Elevated ALT (>30 U/L) associated with waist circumference and insulin resistance even in young population; males OR 7.7, fasting insulin per 1 SD OR 1.6
Bedogni G, et al. • BMC Gastroenterology • 2006
FLI <30 rules out fatty liver (negative LR=0.2, sensitivity 87%); FLI ≥60 rules in fatty liver (positive LR=4.3, specificity 86%).
Ruhl CE, Everhart JE • Gastroenterology • 2005
2+ cups of coffee daily associated with lower GGT and liver disease risk
Whitfield JB • Crit Rev Clin Lab Sci • 2001
Established GGT as a key marker beyond alcohol detection