Curated scientific studies with plain-English summaries and multi-paradigm interpretation
Showing 10 studies
Siscovick et al. • Circulation • 2017
Secondary CHD prevention: ~10% cardiac death reduction (RR 0.91, 95% CI 0.85-0.98); Heart failure: 9% mortality reduction (RR 0.91, 95% CI 0.83-0.99)
Calder PC • Biochem Soc Trans • 2017
EPA and DHA reduce inflammation through multiple mechanisms including resolvin synthesis.
Stark et al. • Prog Lipid Res • 2016
Most of the world has omega-3 levels below cardioprotective thresholds.
Grosso et al. • Oxidative Medicine and Cellular Longevity • 2014
MDD: effect size 0.56 SD (95% CI 0.20-0.92); EPA-predominant superior to DHA; bipolar disorder effect 0.73-0.74 SD; significant as adjuvant therapy
Grosso et al. • Oxid Med Cell Longev • 2014
EPA-predominant omega-3 supplementation shows benefit for depression.
Mozaffarian & Wu • J Am Coll Cardiol • 2011
Even modest omega-3 intake (250-500 mg/day) reduces cardiovascular mortality.
Calder PC • Nutrients • 2010
Effective anti-inflammatory effects require >2g EPA+DHA daily; EPA-derived eicosanoids 10-100 fold less potent as inflammatory mediators; new steady-state reached within ~4 weeks
Harris WS • Am J Clin Nutr • 2008
The Omega-3 Index is a novel, modifiable risk factor for CHD with clinical utility.
Harris et al. • Atherosclerosis • 2008
Multiple cardioprotective mechanisms explain omega-3 benefits beyond lipid-lowering.
Harris & Von Schacky • Prev Med • 2004
Omega-3 Index ≥8% associated with 70% lower risk of sudden cardiac death compared to <4%.