Research Library

Cancer mortality: daily dosing RR 0.88 (95% CI 0.78-0.98, 10 trials); bolus RR 1.07 (ineffective); VITAL: normal BMI cancer OR 0.76; shift focus to deficient individuals

Cancer mortality: 13% reduction (RR 0.87, 95% CI 0.79-0.96, p=0.005); Cancer incidence: no effect (RR 0.98, 95% CI 0.93-1.03, p=0.42)

Target 25(OH)D levels of 30-50 ng/mL (75-125 nmol/L) recommended for general health; higher targets (40-60 ng/mL) for specific conditions.

Overall ARTI reduction OR 0.88 (95% CI 0.81-0.96); daily/weekly dosing OR 0.81; profound deficiency (<25 nmol/L) + daily dosing OR 0.30 (NNT 4)

Optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health; combined supplementation may be more effective than either alone

Only ~1% of solar UVB reaches earth surface (ozone absorbs 99%); deficiency linked to autoimmune diseases, cancers, CVD, infections, and type 2 diabetes

Vitamin D RDA: 600 IU/day ages 1-70, 800 IU/day ages 71+; target serum 25(OH)D: 20 ng/mL (50 nmol/L); UL 4,000 IU/day for ages 9+

Optimal serum 25(OH)D threshold >32 ng/mL (80 nmol/L); serum rises ~1 ng/mL per 100 IU daily intake; safe upper limit 10,000 IU/day

Deficiency <20 ng/mL, insufficiency 21-29 ng/mL, sufficiency >30 ng/mL; 1,000-2,000 IU daily recommended; women with vitamin D supplementation showed 66% reduced cancer risk

Vitamin D deficiency affects an estimated 1 billion people worldwide, with consequences extending far beyond bone health to include increased risk of cancer, autoimmune disease, and cardiovascular disease.

Vitamin D deficiency predisposes children to respiratory infections; UV radiation and vitamin D supplementation reduce viral respiratory infection incidence