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Phenotype Screener

LMHR Phenotype Screener

Screen for the Lean Mass Hyper-Responder profile — a unique lipid pattern in lean, metabolically healthy individuals on low-carb diets where high LDL occurs alongside excellent HDL and triglycerides

Metabolic Relevance
LMHR is defined by three simultaneous findings: LDL ≥200 mg/dL, HDL ≥80 mg/dL, and TG ≤70 mg/dL. Unlike typical high-LDL patterns (which come with low HDL and high TG), LMHR shows the opposite — this reversed pattern suggests a fundamentally different metabolic context where LDL particles may serve an energy transport function.

Important context:
LMHR is rare in overweight individuals. The leaner and more active you are on low-carb, the more likely this pattern emerges. CAC score provides important additional cardiovascular context.

Did you know?

LMHR is fully reversible — adding 100-150g of carbs daily reverses the lipid profile within weeks, suggesting a metabolic (not genetic) cause. This reversibility is a key distinguishing feature.

The recent KETO-CTA study showed some LMHR individuals do develop atherosclerosis despite metabolic health markers. Individual assessment with CAC scoring is essential for personalized risk evaluation.

Want to understand your result better?

Learn about interpretation, what affects your score, and evidence-based strategies to improve it.

Read the full guide

Evidence-Based

This calculator is based on peer-reviewed research validated across thousands of clinical studies.

View scientific references(5)

Medical Disclaimer

This calculator is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician or other qualified health provider with any questions you may have regarding your health.

Understanding the LMHR Pattern

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Standard Medical

Views high LDL (≥200 mg/dL) as cardiovascular risk

⚠️ Context-independent LDL assessment

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Lipid Energy Model

LDL particles as energy transport in keto-adapted lean individuals

🔬 Hypothesis under active investigation

Metabolic Context

Full triad (LDL ≥200, HDL ≥80, TG ≤70) with metabolic health

CAC score essential for individual risk assessment